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Endomysium, Reticulin & Gliadin-IgA |
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Indirect Immunofluorescence method
Biochip Titerplane Technique
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Anti Endomycium |
Anti
Gliadin |
Anti Endomycium |
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Primate intestine |
Gliadin coated chip |
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Primate Liver section |
CLINICAL SIGNIFICANCE
Determination of IgA antibodies against Endomysium ,Reticulin and Gliadin
provides confirmation of clinical diagnosis of gluten-sensitive enteropathy(small children
:coeliac disease,adults:non-tropical sprue).Reticulin antibodies are found in 60% of celiac
disease patients. Endomysium antibodies possess a higher specificity and is used as
means of determining the predisposition for gluten sensitive enteropathy among relatives
of patients with coeliac disease.
Determination of antibodies against gliadin is also
suitable for monitoring the course of therapy or a gluten loading test and for asessing
the compliance of a gluten-free diet. Usually endomycium and gliadin antibodies
occur together however,they are not identical and may not correlate with each other in all cases.
Some patients with
gluten-sensitive enteropathy also suffer from Duhring's dermatitis herpetiformis, a chronic skin disease connected with the formation of blisters.This disease can also appear by itself.
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