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Granular
fluorescence of the cytoplasm ( cANCA ) is specific for
Wegener's granulomatosis. 90% of cases test positive during
the active stage while only 30 to 40%
of cases test positive during remission stage.Target antigen
is Proteinase-3.
Presence of anti myeloperoxidase ( pANCA ) can indicate
rapid-progressive
glomerulonephritis, microscopic polyangitis and other forms of
vasculitis.
In ulcerative colitis, primary sclerosing cholangitis and
other diseases pANCA are also found,which mainly do not react
with myeloperoxidase, but are directed against other not yet
identified target antigens.
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