| 1. |
Anti UI-nRNP |
High
titres present in 95%-100% of patients with mixed
connective tissue disease, Sharp syndrome.The titre correlates with the clinical activity of the disease.Also found in 30-40% of patients with disseminated lupus in combination with anti smith. |
| 2. |
Anti-Smith |
Highly specific and present in 20%-40% of patients with disseminated lupus . |
| 3. |
Anti SS-A |
Present in patients with Sjogren's
Syndrome (40%-80%), disseminated lupus(30-40%), primary billary
cirrosis (20%), neonatal lupus (100%), occationally in chronic active
hepatitis. New born babies some times may get congenital heart block because of
anti SS-A when they are transmitted to the foetus from mother. |
| 4. |
Anti SS-B |
Found in Sjogren's syndrome(40-80%)mostly in
women, disseminated lupus(10-20%). |
| 5. |
Anti Scl-70 |
Found in diffuse progressive systemic sclerosis(25%-75%). |
| 6. |
Anti PM-Scl |
Found in 50-70% of patien's with overlap syndrome. |
| 7. |
Anti
Jo-1 |
Found in polymyositis(25%-35%),mostly associated with a concurrent interstitial
fibrosis of the lung. |
| 8. |
Anti-Centromere |
Found in 70%-90% of patients with limited form of progressive systemic sclerosis. (CREST
syndrome, calcinosis, Raynaud's disease, esophageal dysfunction,
sclerodactylia, teleangiectasia). |
| 9. |
Anti
ds-DNA |
Specific for systemic lupus erythematosus(40%-90%). |
| 10. |
AntiNucleosomes |
Specific/marker for
SLE. |
| 11. |
Anti-Histones |
Found in drug induced lupus(95%),disseminated lupus(30%-70%),rheumatoid
arthiritis(15%-50%). |
| 12. |
Anti-ribosomal |
More specific for systemic lupus. Also frequently found in patients with psychoses, P-Proteins but not significant. |
| 13. |
AMA-M2 |
Are charecteristic of primary biliary liver cirrhosis.. |
